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Most Virulent Disease Dengue, a viral disease carried by mosquitoes, and its more serious variant, dengue hemorrhagic fever (DHF), are probably the most widespread reemerging diseases. In 1998 there were 1.2 million cases of dengue and DHF reported. Over 15,000 of these cases led to deaths.

Dengue is a mosquito-born viral disease that burdens tropical regions around the world. Yearly, in addition to tens of millions of cases of severe dengue fever, an average of 500,000 persons, mostly children, are hospitalized with dengue hemorrhagic fever with high case fatality rates. No specific treatment is available. The 20-21st century dengue pandemic is the direct result of contemporary demographic and life-style trends - the population explosion, urbanization and rapid transportation of large numbers of people. Vector-control strategies have been insufficient to counter this pandemic.

Needs for Dengue Vaccines


A survey of policy makers and public health professionals in four South East Asian countries was conducted to determine policy makers' views on the public health importance of dengue fever and dengue hemorrhagic fever, the need for the vaccines. The survey outcome revealed a uniformly high level of concern about dengue fever/DHF and a high and urgent perceived need for a dengue vaccine. Most Virulent Disease Dengue, a viral disease carried by mosquitoes, and its more serious variant, dengue hemorrhagic fever (DHF), are probably the most widespread reemerging diseases. In 1998 there were 1.2 million cases of dengue and DHF reported. Over 15,000 of these cases led to deaths.